New natural products as new leads for antibacterial drug discovery

Dean G Brown; Troy Lister; Tricia L May-Dracka

doi:10.1016/j.bmcl.2013.12.059

New natural products as new leads for antibacterial drug discovery

Bioorg Med Chem Lett. 2014 Jan 15;24(2):413-8. doi: 10.1016/j.bmcl.2013.12.059. Epub 2013 Dec 22.

Authors

Dean G Brown¹, Troy Lister², Tricia L May-Dracka²

Affiliations

¹ AstraZeneca Pharmaceuticals, 35 Gatehouse Dr, Waltham, MA 02451, United States. Electronic address: dean.brown@astrazeneca.com.
² AstraZeneca Pharmaceuticals, 35 Gatehouse Dr, Waltham, MA 02451, United States.

PMID: 24388805
DOI: 10.1016/j.bmcl.2013.12.059

Abstract

Natural products have been a rich source of antibacterial drugs for many decades, but investments in this area have declined over the past two decades. The purpose of this review article is to provide a recent survey of new natural product classes and the mechanisms by which they work.

Keywords: Antibacterial; Antimicrobial; Natural products.

Publication types

Review

MeSH terms

Animals
Anti-Bacterial Agents / chemistry*
Biological Products / chemistry*
Crystallography, X-Ray
Drug Discovery / methods
Drug Discovery / trends*
Humans

Substances

Anti-Bacterial Agents
Biological Products